EDK
Editome Disease Knowledgebase
Alzheimer's Disease
| Disease name | Alzheimer's Disease |
|---|---|
| Classfication | Nervous system disease |
| Related Enzyme(s) | |
| EFO | EFO:0000249 |
| DOID | 10652 |
| OMIM | |
| NCI | |
| Definition | Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time. |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| GRIA2 | Human;Rat;Mouse | ADAR2 | 1 | A-to-I | RNA editing levels at the GluA2 Q/R site is an association with some nervous system diseases and glioma. |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-miR-132-3p | - | 2 | A-to-I | MIMAT0000426 | Compared to non-demented controls, miR-132-3p is significant downregulated in AD, FTLD, and PSP cases. |